Research in virology is revealing potential links between ancient viral infections and neurodegenerative diseases like Alzheimer’s. Laboratories worldwide, including IrsiCaixa in Spain, are investigating how these viruses may contribute to cognitive decline. Approximately one-third of the human genome consists of remnants from ancient viral infections, which may occasionally reactivate, causing inflammation and neuronal damage.
Current hypotheses suggest that when these viral remnants activate in brain cells, they trigger an immune response that continuously produces inflammatory molecules, potentially accelerating the progression of Alzheimer’s disease. Studies conducted by the Center for Genomic Regulation (CRG) and IrsiCaixa have shown promising results in animal models, indicating that antiviral drugs, such as lamivudine used for HIV treatment, may improve conditions by reducing neuroinflammation.
Independent observational studies of HIV patients have noted a lower incidence of Alzheimer’s among those using antivirals that target these viral fossils. A new clinical trial has been initiated to assess the effectiveness of lamivudine in slowing early-stage Alzheimer’s decline, backed by collaborative efforts from various foundations and hospitals.
This research points to a potential paradigm shift in Alzheimer’s treatment, emphasizing genetics and early detection. While effective treatments currently exist, they are limited in benefit and may cause side effects. However, the emergence of research focused on safe and accessible antiviral medications signifies a step forward in addressing this global health challenge.
- Why it matters: Insights into the relationship between viral infections and Alzheimer’s could lead to new therapeutic strategies, impacting treatment accessibility and effectiveness for millions.
- Study findings may enhance our understanding of neurodegenerative processes, providing a basis for further public health interventions.
- The latest: A clinical trial is underway to evaluate the effects of lamivudine on neuroinflammation in Alzheimer’s patients, marking a significant step in research efforts.
Source: https://en.ara.cat/science-technology/what-if-viruses-embedded-in-your-dna-hold-the-key-to-stopping-alzheimer-s_129_5518458.html
Source: https://en.ara.cat/science-technology/what-if-viruses-embedded-in-your-dna-hold-the-key-to-stopping-alzheimer-s_129_5518458.html