As winter approaches, the flu season is also returning, driven by influenza viruses that infect cells via droplets. Researchers from Switzerland and Japan have utilized a unique microscopy method they developed to observe in detail how these viruses enter human cells. This study, led by Yohei Yamauchi from ETH Zurich, enabled live, high-resolution imaging of the cellular infection process.
Findings indicate that cells are not merely passive during infection; rather, they actively engage with the virus. The influenza virus utilizes a cellular uptake mechanism designed for vital substances like hormones and cholesterol to facilitate its entry. The virus attaches to specific receptor molecules on the cell surface, resembling a “surfing” action as it seeks suitable entry points. Once attached, the cell responds by forming a pocket, aided by a structural protein called clathrin, which encapsulates the virus into a vesicle for transport into the cell.
The newly developed technique, called virus-view dual confocal and atomic force microscopy (ViViD-AFM), combines methods to track the dynamics of viral entry in real time. This advancement is significant for antiviral drug development, as it allows researchers to test potential treatments within living cell cultures. The technique also holds promise for studying other viruses and vaccines.
- Why it matters:
- This research could lead to effective antiviral drugs, impacting public health during flu season.
- Understanding virus-cell interactions may enhance vaccine development strategies.
- The latest:
- The new microscopy method provides insights into real-time dynamics of viral infection, crucial for future research.
Source: https://www.miragenews.com/influenza-viruses-pathway-to-cell-invasion-1583440/
Source: https://www.miragenews.com/influenza-viruses-pathway-to-cell-invasion-1583440/