Researchers from Integrated DNA Technologies, including Director of Technology R&D Adam Clore, indicate that ongoing developments in AI technologies necessitate continual testing in the field of DNA synthesis. While advancements have been made, Clore acknowledges that the current strategies are not exhaustive, describing the situation as akin to an “arms race.”
In the interest of safety, certain code details have not been disclosed, and specific toxic proteins targeted by an AI redesign remain confidential. However, well-known dangerous proteins, such as ricin and infectious prions linked to mad-cow disease, highlight the potential risks. Dean Ball, a fellow at the Foundation for American Innovation, emphasizes the urgent need for improved screening procedures for nucleic acid synthesis, along with effective enforcement and verification mechanisms. He points out that the U.S. government recognizes the importance of DNA order screenings for national security. An executive order issued by President Trump in May called for a comprehensive revision of the existing safety protocols, though updated recommendations have not yet been released.
Some experts, like Michael Cohen from the University of California, Berkeley, argue that commercial DNA synthesis may not be the most effective strategy to counter potential threats. He suggests that there will always be methods for evading detection and criticizes the rigor of current testing methods. Cohen advocates for integrating biosecurity measures directly into AI systems.
In contrast, Clore believes that monitoring the synthesis of DNA remains a viable method for identifying biothreats. He points out that the U.S. industry is primarily comprised of a limited number of companies that maintain close collaboration with government entities, making oversight more feasible. Clore warns that given the widespread availability of AI technology, evading oversight has become increasingly possible.
Source: https://www.technologyreview.com/2025/10/02/1124767/microsoft-says-ai-can-create-zero-day-threats-in-biology/