Rawle lab investigates viral infection – The Williams Record

At the College, Associate Professor of Chemistry Bob Rawle leads a lab focused on studying how viruses interact with model lipid membranes. The lab examines viruses such as the Sendai virus and Dengue virus-like particles (VLPs). Prior to his position, Rawle conducted doctoral and postdoctoral research at Stanford, where he explored the biophysics of influenza and Zika viruses.

The lab environment is designed to ensure safety, as the Sendai virus cannot infect humans, and VLPs lack the necessary genetic material to be infectious. Student researchers tackle various projects, including the creation of artificial lipid bilayers to control experimental conditions. One student, Katherine Bai ’26, is writing her thesis on the binding mechanism of the Sendai virus, investigating factors that affect infection processes.

Additionally, Miranda Kimm ’26 and Alice Walker ’27 are studying how Dengue-like viruses interact with model lipid membranes through fusion assays. The lab collaborates with Priscilla Yang, a microbiology professor at Stanford, to research the molecular fusion mechanism of the Dengue virus.

Rawle’s lab is also working on developing new model membranes from human red blood cells for bioanalytical studies. This research may have significant implications for biotechnology and antiviral drug development. Recently, the lab created a TikTok account to share lab experiences and enhance team dynamics.