Research from Stanford Medicine, published in Science Translational Medicine, has identified a potential link between the Epstein-Barr virus (EBV) and systemic lupus erythematosus (lupus). EBV is widely present in the U.S. population, with over 94% of adults carrying the virus, which typically causes mild symptoms or none at all. However, in several hundred thousand Americans and about 5 million people globally diagnosed with lupus, the immune system attacks the body’s own cells, leading to various health issues, including skin rashes and organ damage.
This study found that in lupus patients, a significantly higher number of B cells carry EBV compared to healthy individuals. In people with lupus, approximately 25 EBV-infected B cells per 10,000 were identified, in contrast to just one per 10,000 in healthy controls. The researchers discovered that EBV alters immune cell functionality, transforming some B cells into potent antigen presenters, which may ultimately contribute to the development of lupus. This research provides insights into the mechanisms of the disease and suggests that specific genetic factors, along with viral interaction, may lead to autoimmunity.
The findings are significant as they help clarify the connection between a common virus and a complex autoimmune disease, potentially informing future treatments and preventive strategies.
- Why it matters: This study could lead to better understanding and treatment options for lupus, a disease affecting millions worldwide.
- Continued research may uncover targeted therapies for at-risk populations, improving patient outcomes.
- The latest: The study indicates that EBV’s role in lupus extends beyond mere correlation, suggesting a mechanism for how the virus influences autoimmune responses.
Source: https://www.thebrighterside.news/post/virus-found-in-94-of-adults-could-be-the-cause-of-lupus-study-finds/
Source: https://www.thebrighterside.news/post/virus-found-in-94-of-adults-could-be-the-cause-of-lupus-study-finds/