Unexpected redundancy or harmfulness of plasmacytoid dendritic cells in viral infections

Unexpected redundancy or harmfulness of plasmacytoid dendritic cells in viral infections

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Research Summary: A study by Ngo, C. et al. published in Nature Immunology explores the role of plasmacytoid dendritic cells in various viral infections. The researchers found these cells may be either unnecessary or potentially harmful during murine systemic and respiratory viral infections. The findings suggest that targeting these cells could warrant investigation in therapeutic contexts.

  • Why it matters:
    • The findings could reshape the understanding of immune responses in viral infections, potentially affecting treatment strategies.
    • Businesses focused on immunotherapy and virology may need to reconsider the role of dendritic cells in their research and development programs.
  • The latest: Comprehensive results from this study were published in 2025, highlighting the need for further exploration of dendritic cell functions in viral contexts.

Source: https://www.nature.com/articles/s41590-025-02322-4

Source: https://www.nature.com/articles/s41590-025-02322-4

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